PLEKHA7 modulates epithelial tight junction barrier function

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PLEKHA7 modulates epithelial tight junction barrier function

PLEKHA7 is a recently identified protein of the epithelial zonula adhaerens (ZA), and is part of a protein complex that stabilizes the ZA, by linking it to microtubules. Since the ZA is important in the assembly and disassembly of tight junctions (TJ), we asked whether PLEKHA7 is involved in modulating epithelial TJ barrier function. We generated clonal MDCK cell lines in which one of four diff...

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ژورنال

عنوان ژورنال: Tissue Barriers

سال: 2014

ISSN: 2168-8370

DOI: 10.4161/tisb.28755